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Methylation support; Cellular energy; Heart and vascular health; Brain function; Mood support
Adults with busy lifestyles seeking focused methylation support or those with limited intake of B-rich foods.
Take 1 to 3 capsules daily, preferably with meals; spreading doses across the day may enhance tolerance.
Gluten Free
Provides methyl groups to support homocysteine remethylation and overall methylation balance.
Caution: May cause stomach upset in some people; take with food if sensitive.
Acts as a cofactor for methionine synthase, helping convert homocysteine to methionine and supporting methylation-dependent processes.
Caution: High doses may be stimulating for some individuals; avoid taking close to bedtime if sensitive.
Delivers the active folate form used in one-carbon metabolism to donate methyl groups and support DNA and neurotransmitter synthesis.
Caution: Consult a health professional before use during pregnancy or when taking medications that interact with folate status.
Functions as an active coenzyme in amino acid metabolism, including transsulfuration pathways related to homocysteine balance.
Caution: Long-term high intakes may be associated with nerve tingling; follow suggested use.
Provides the active form of vitamin B2 that supports redox reactions and the folate cycle enzymes involved in methylation.
Caution: May cause bright yellow urine due to riboflavin excretion; this is harmless.
Trimethylglycine and methylcobalamin donate and transfer methyl groups to help remethylate homocysteine. L-5-methyltetrahydrofolate supplies the active folate used in one‑carbon metabolism, while PLP (B6) and R5P (B2) act as active coenzymes that help drive folate and amino acid pathways for efficient methylation.
Label Warning: If pregnant, consult a healthcare practitioner before use.
Who should be cautious: People with high vitamin B intake sensitivity or those with a history of vitamin-related neuropathy may want to discuss the high-dose B vitamins with a healthcare provider before use.
Storage: Store tightly sealed in a cool, dry place.
Many reviewers mention more steady energy, sharper focus, and clearer thinking after regular use.
Users who prefer methylfolate and methylcobalamin note they feel benefits and find the forms easy to use.
Some users find the capsule size on the bigger side, which may be less comfortable for some.
This product is guaranteed authentic and backed by our easy returns & refunds policy. Details
Magnesium and B vitamins may support energy production and reduce fatigue, promoting overall vitality and well-being.
AI generated. Not medical advice.
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Support cellular energy production, heart health, brain function, and mood with nutrients that optimize methylation
Methyl-Guard Plus provides superior methyl donors – trimethylglycine, 5-MTHF, and methylcobalamin – combined with bioactive vitamins B2 and B6 in a powerhouse formula for whole-body methylation support.
Take 1-3 capsules daily or as recommended by a health-care practitioner.
Hypromellose (derived from cellulose) capsule, calcium citrate, calcium laurate.
Manufactured in the USA using US & Imported ingredients.
Tamper Evident: Use only if bottle is sealed. Store tightly sealed in a cool, dry place.
If pregnant, consult your health-care practitioner before using this product.
While iHerb strives to ensure the accuracy of its product images and information, some manufacturing changes to packaging and/or ingredients may be pending update on our site. Although items may occasionally ship with alternate packaging, freshness is always guaranteed. We recommend that you read labels, warnings and directions of all products before use and not rely solely on the information provided by iHerb.
| Supplement facts | ||
| Serving Size: Three Capsules | ||
| Servings Per Container: 30 | ||
| Three Capsules Contain: | %DV | |
| Riboflavin (as Riboflavin 5'-Phosphate Sodium) | 90 mg | 6,923% |
| Vitamin B6 (as Pyridoxal 5'-Phosphate) | 45 mg | 2,647% |
| Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) | 5 mg DFE | 1,250% |
| Vitamin B12 (as Methylcobalamin) | 3 mg | 125,000% |
| Betaine Anhydrous (Trimethylglycine) | 1.8 g | * |
| *Daily Value (DV) not established. †This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolic Acid, Glucosamine Salt (Quatrefolic). | ||
